Redox-responsive mesoporous silica nanoparticles for chemo- photodynamic combination cancer therapy

Abstract Traditional chemotherapy remains the primary cancer treatment, but it shows low enrichment and non-specificity. Hence, we have designed a multifunctional nanocarrier based on glutathione (GSH)-responsive mesoporous silica nanoparticles (MSNs). Firstly, disulfide bonds were linked surface of silica. Then, doxorubicin (DOX) chlorin e6 (Ce6) co-loaded into pores. Finally, carboxymethyl chitosan (CMCS) coated to obtain DOX/Ce6@MSN-SS-CMCS (DOX/Ce6@MSC) nanocarrier. The synthesized DOX/Ce6@MSC showed good monodispersity, dimensional stability, consistent spectral characteristics. could effectively enter cells successfully deliver drugs. Under 660 nm laser irradiation, exhibited an effective photodynamic therapy effect that resists MCF-7 by triggering reactive oxygen species production. Thereby, efficiently inhibit cell proliferation induce death. Anticancer analysis tumor-bearing mice demonstrates combination treatment induced apoptosis excellent antitumor in vivo . Therefore, nano-drug delivery system be strategy treatment.